Structure–Activity Relationship and Pharmacokinetic Studies of 1, 5-Diheteroarylpenta-1, 4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents

R Wang, C Chen, X Zhang, C Zhang…

文献索引：Cao, Bin; Wang, Yong; Ding, Kan; Neamati, Nouri; Long, Ya-Qiu Organic and Biomolecular Chemistry, 2012 , vol. 10, # 6 p. 1239 - 1245

全文：HTML全文

被引用次数: 11

摘要

Forty-three 1, 5-diheteroaryl-1, 4-pentadien-3-ones were designed as potential curcumin mimics, structurally featuring a central five-carbon dienone linker and two identical nitrogen- containing aromatic rings. They were synthesized using a Horner–Wadsworth–Emmons