Synthesis

A simple and efficient one-pot synthesis of 2-substituted benzimidazoles

K Bahrami, MM Khodaei, I Kavianinia

文献索引：Bahrami, Kiumars; Khodaei, Mohammad Mehdi; Kavianinia, Iman Synthesis, 2007 , # 4 p. 547 - 550

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被引用次数: 121

摘要

Abstract A simple and efficient procedure for the synthesis of substituted benzimidazoles through a one-pot condensation of o-phenylenediamines with aryl aldehydes in the presence of H 2 O 2/HCl system in acetonitrile at room temperature is described. Short reaction time, large-scale synthesis, easy and quick isolation of the products, and excellent yields are the main advantages of this procedure.