Antimalarial phenanthrene amino alcohols. 2. Trifluoromethyl-containing 9-phenanthrenemethanols

EA Nodiff, AJ Saggiomo, M Shinbo…

文献索引：Nodiff,E.A. et al. Journal of Medicinal Chemistry, 1972 , vol. 15, p. 775 - 780

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被引用次数: 12

摘要

LiAlH,. The mixt was stirred at room temp for 29 hr. The reaction was hydrolyzed with H,O and extracted with Et,O. The Et,O soln was evapd in vacuo to yield 3.0 g of crude product. Tlc showed a number of spots (silica gel-C,H,). The crude reaction product was chromatographed on a 28 X 3 cm column of silica gel (C,H, elution, 60-ml fractions). Fractions 6-12 gave 500 mg of the starting amino ketone (15%) (nmr, ir). Fractions 22-29 (10% Et,O) gave 500 mg of product ...