The Journal of Organic Chemistry

Carboxyalthioacrylates

PD Halphen, TC Owen

文献索引：Halphen,P.D.; Owen,T.C. Journal of Organic Chemistry, 1973 , vol. 38, # 20 p. 3507 - 3510

全文：HTML全文

被引用次数: 26

摘要

I I1 I11 suitably constructed thioacrylates might well be useful intermediates in the synthesis of such fused P-lactam antibiotics, the group X providing the nitrogen atom, and either X or the thioacrylate function the carbonyl group. Thioacrylates, moreover, are conveniently prepared in either the cis or the trans geometry, and preservation of this geometry during cyclization might permit a stereoselective penicillin-cephalosporin synthesis.