Synthesis

Selective synthesis of carbamate protected polyamines using alkyl phenyl carbonates

M Pittelkow, R Lewinsky, JB Christensen

文献索引：Pittelkow, Michael; Lewinsky, Rasmus; Christensen, Jorn Bolstad Synthesis, 2002 , # 15 p. 2195 - 2202

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被引用次数: 55

摘要

Abstract Utilising alkyl phenyl carbonates, an economical, practical and versatile method for selective Boc, Cbz and Alloc protection of polyamines has been developed. This method allows Boc, Cbz and Alloc protection of primary amines in the presence of secondary amines by reaction of the polyamines with the alkyl phenyl carbonates. Also, this method allows mono carbamate protection of simple symmetrical aliphatic α, ω-alkanediamines in ...