Synthesis and Carcinogenic Activity of Oxidized Benzacridines: Potential Metabolites of the Strong Carcinogen 7-methylbenz [c] acridine and of the Inactive Isomer 12- …

M Croisy-Delcey, A Croisy, F Zajdela…

文献索引：Croisy Delcey; Croisy; Zajdela; Lhoste Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 303 - 306

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被引用次数: 25

摘要

The synthesis of 15 compounds related either to the benz [c] acridine or to the benz [a] acridine series is reported. Spectral data, ie, NMR and E1 fragmentation, are given. These compounds were tested for carcinogenic activity in mice of the XVIInc/Z strain by subcutaneous injection. Only three weak carcinogens were detected, 5, 6-di-hydro-5, 6- dihydroxy-l2-methylbenz [a] acridine, 3-methoxy-7-methylbenz [c] acridine, and 4-acetoxy- ...