Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease
Curtis R. Warren, John F. O’Sullivan, Max Friesen, Caroline E. Becker, Xiaoling Zhang, Poching Liu, Yoshiyuki Wakabayashi, Jordan E. Morningstar, Xu Shi, Jihoon Choi, Fang Xia, Derek T. Peters, Mary H.C. Florido, Alexander M. Tsankov, Eilene Duberow, Lauren Comisar, Jennifer Shay, Xin Jiang, Alexander Meissner, Kiran Musunuru, Sekar Kathiresan, Laurence Daheron, Jun Zhu, Robert E. Gerszten, Rahul C. Deo, Ramachandran S. Vasan, Christopher J. O’Donnell, Chad A. Cowan
As part of the NHLBI NextGen consortium, Warren et al. show that analyzing the cellular pathophysiology of cells differentiated from multiple lines of an iPSC library is a promising complementary approach in the functional analysis of GWAS variants.