Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

…, M Porcelloni, P D'Andrea, CI Fincham, A Ettorre…

文献索引：Rossi, Cristina; Porcelloni, Marina; D'Andrea, Piero; Fincham, Christopher I.; Ettorre, Alessandro; Mauro, Sandro; Squarcia, Antonella; Bigioni, Mario; Parlani, Massimo; Nardelli, Federica; Binaschi, Monica; Maggi, Carlo A.; Fattori, Daniela Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2305 - 2308 Title/Abstract Full Text View citing articles Show Details Rossi, Cristina; Fincham, Christopher I.; D'Andrea, Piero; Porcelloni, Marina; Ettorre, Alessandro; Mauro, Sandro; Bigioni, Mario; Binaschi, Monica; Maggi, Carlo A.; Nardelli, Federica; Parlani, Massimo; Fattori, Daniela Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6767 - 6769

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被引用次数: 12

摘要

We report here the strategy used in our research group to find a new class of histone deacetylase (HDAC) inhibitors. A series of N-substituted 4-alkylpiperazine and 4- alkylpiperidine hydroxamic acids, corresponding to the basic structure of HDAC inhibitors (zinc binding moiety-linker-capping group) has been designed, prepared, and tested for HDAC inhibition. Linker length and aromatic capping group connection were ...