Chemistry Letters

4-Chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate: a useful phosphorylating agent for guanosine 3′-phosphotriester

H Takaku, K Kamaike, K Kasuga

文献索引：Takaku, Hiroshi; Kamaike, Kazuo; Kasuga, Kenichi Chemistry Letters, 1982 , p. 197 - 200

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被引用次数: 14

摘要

5′-O-Dimethoxytrityl-2′-O-tetrahydropyranyl-N 2-benzoylguanosine smoothly reacts with 4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate in the presence of 8- quinolinesulfonyltetrazolide (QS-te) to give 5′-O-dimethoxytrityl-2′-O-tetrahydropyranyl-N 2-benzoylguanosine 3′-(4-chlorophenyl, 5-chloro-8-quinolyl) phosphate in high yield without a side product such as O 6-phosphorylated guanosine.