Synthesis and structure-activity relationships of novel phenylcyanoguanidine derivatives as potassium channel openers.

…, N NISHIMURA, T SUKAMOTO, K YOSHINO

文献索引：Yoshiizumi, Kazuya; Ikeda, Shoji; Goto, Katsumi; Morita, Tominori; Nishimura, Noriyasu; Sukamoto, Takayuki; Yoshino, Kohichiro Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 11 p. 2042 - 2050

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被引用次数: 8

摘要

3, 5-Di-substituted phenylcyanoguanidine derivatives with halogen, cyano, and/or nitro groups at the 3-and 5-positions of the benzene ring exhibited very strong smooth muscle relaxation activity in vitro, as compared to pinacidil. Among them, N-(3-chloro-5- cyanophenyl)-N'-cyano-N"-tert-pentylguanidine (5s) showed 27-fold more potent activity than pinacidil, and exhibited a stronger and more lasting antihypertensive effect than ...