Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors

Y Wang, J Ai, G Liu, M Geng, A Zhang

文献索引：Wang, Yuanxiang; Ai, Jing; Liu, Gang; Geng, Meiyu; Zhang, Ao Organic and Biomolecular Chemistry, 2011 , vol. 9, # 17 p. 5930 - 5933

全文：HTML全文

被引用次数: 7

摘要

An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedländer's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure–activity relationship (SAR) study.