By working in sufficiently acidic solutions, the amidation reaction was They were very high (10'1. group rendered the latter inert to acylation by ethyl chloroformate in water. studies of the amidation of ethyl chloroformate. slowed to measurable range. Semi-quantitative bimolecular rate constants were obtained. mole-'sec.-l for piperidine) and were markedly decreased by steric hindrance in the amine.
