Synthesis and antiarrhythmic activity of new 3-[2-(. omega.-aminoalkoxy) phenoxy]-4-phenyl-3-buten-2-ones and related compounds

A Salimbeni, E Manghisi, GB Fregnan…

文献索引：Salimbeni, Aldo; Manghisi, Elso; Fregnan, Giancarlo B.; Prada, Marco Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 773 - 780

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被引用次数: 4

摘要

(3) Low-power specific lH-decoupling experiments on compound 9c (see 13C NMR spectrum in the Experimental Section) indicate that C-1'is coupled (J= 6.5 and 3.5 Hz) to H- 3'and H-6', while C-2'is coupled (J= 6.5 and 6.5 Hz) to H-4'and H-6'. As a consequence, the chlorine atom must be located at the C-5'position. The above lH-13C coupling values are in good agreement with those for the corresponding three-bond (C, H) couplings (3J= 5-11 ...