Pd-Catalyzed direct arylation approach to the 6H-dibenzo [c, h] chromenes: Total synthesis of arnottin I

S De, S Chaudhuri, S Mishra, H Mamtani…

文献索引：De, Subhadip; Chaudhuri, Saikat; Mishra, Sourabh; Mamtani, Himanshu; Bisai, Alakesh Journal of the Indian Chemical Society, 2013 , vol. 90, # 10 p. 1871 - 1884

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被引用次数: 1

摘要

Abstract: An efficient synthesis of 6H-dibenzo [c, k] chromenes has been achieved from 2- bromobenzyl-ot-naphthyl ethers via a Pct-catalyzed intramolecular direct-arylation using easily available Pdtl'PhJ) 4 or Pd (0Ac) zlPPh3 at elevated temperature. The reaction affords biaryl-coupling products in good to excellent yields in 6-9 h (up to 94% yields). A tentative mechanism has been proposed to understand the reaction pathway. Applying the ...