Acidic Properties of Benzimidazoles and Substituent Effects. V. Protection of Benzimidazoles by N-Alkyl Bond Formation using Vinylpyridines

M ICHIKAWA, C YAMAMOTO…

文献索引：Ichikawa, Masataka; Yamamoto, Chiyuki; Hisano, Takuzo Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 3042 - 3047

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被引用次数: 3

摘要

Vinylpyridines were utilized for protection of the benzimidazole NH bond to give 1-(2- pyridylethyl)-benzimidazoles. The reaction was found to progress smoothly when glacial acetic acid was used as a catalyst. In the alkylation of 5-or 7-substituted-2- arylbenzimidazoles with vinylpyridines, the yield decreased with increasing electronattracting effect of the substituent groups in the benzimidazole ring. On the other ...