Abstract A series of pyridines were synthesized and evaluated as bronchospasmolytic/anti- allergic agents. Several of these compounds were found to: 1) inhibit the release of histamine; 2) antagonize histamine, bradykinin, LTD 4 and PAF; 3) suppress the IgE- mediated passive cutaneous anaphylaxis (PCA) reaction. The most interesting substance of this series 2, 6-dimethyl-3-nitro-4 [(2-(4-diphenylmethyl-1-piperazinyl) ethyl) amino] ...
![4-[2-(4-benzhydrylpiperazin-1-yl)ethylimino]-1-hydroxy-2,6-dimethylpyridine-3-carbonitrile,trihydrochloride结构式](https://image.chemsrc.com/caspic/434/110629-32-8.png)
![N-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-N,4,6-trimethyl-5-nitropyridin-2-amine,trihydrochloride结构式](https://image.chemsrc.com/caspic/310/110629-35-1.png)
![N-[2-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]ethyl]-2,6-dimethyl-3-nitropyridin-4-amine,trihydrochloride结构式](https://image.chemsrc.com/caspic/234/110629-37-3.png)
![N-[3-(4-benzhydrylpiperazin-1-yl)propyl]-2,6-dimethyl-3-nitropyridin-4-amine,trihydrochloride结构式](https://image.chemsrc.com/caspic/365/110629-29-3.png)
![2,6-dimethyl-3-nitro-N-[2-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]ethyl]pyridin-4-amine,trihydrochloride结构式](https://image.chemsrc.com/caspic/010/110629-30-6.png)
![N-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethyl]-2,6-dimethyl-3-nitropyridin-4-amine,trihydrochloride结构式](https://image.chemsrc.com/caspic/272/110629-36-2.png)