Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides

…, GW Rewcastle, GJ Atwell, BC Baguley…

文献索引：Palmer; Rewcastle; Atwell; Baguley; Denny Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 707 - 712

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被引用次数: 94

摘要

Structure-antitumor activity relationships are reported for a number of different examples (acridine, phenazine, anthracene, acridone, xanthenone, thioxanthenone, anthraquinone, pyridoquinazoline, dibenzodioxin, thianthrene, phenothiazine, phenoxazine, dibenzofuran, carbazole, and pyridoindole) of the general class of N-[2-(dimethylamino) ethyl] linear tricyclic carboxamides. Only the compounds containing coplanar chromophores ...