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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

6-(Alkylamino)-9-benzyl-9H-purines. A new class of anticonvulsant agents

…, MP Krochmal, JA Linn, EW McLean…

文献索引：Kelley, James L.; Krochmal, Mark P.; Linn, James A.; McLean, Ed W.; Soroko, Francis E. Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 606 - 612

全文：HTML全文

被引用次数: 40

摘要

Several 9-alkyl-6-substituted-purines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. Most compounds were prepared in three steps from 5-amino-4, 6-dichloropyrimidine or in two steps via alkylation of 6-chloropurine. Potent anticonvulsant activity against MES resided in compounds that contain a benzyl substituent at the 9-position of 6-(methylamino)-or 6-(dimethylamino) ...

二甲胺结构式

9-[4-(benzyloxy)benzyl]-6-chloro-9H-purine结构式

9-[4-(benzyloxy...

~61%

N,N-dimethyl-9-[(4-phenylmethoxyphenyl)methyl]purin-6-amine结构式

N,N-dimethyl-9-...

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4-苄氧基苯甲醛结构式

4-苄氧基苯甲醛

~%

N,N-dimethyl-9-[(4-phenylmethoxyphenyl)methyl]purin-6-amine结构式

N,N-dimethyl-9-...

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4-苄氧基苄醇结构式

4-苄氧基苄醇

~%

N,N-dimethyl-9-[(4-phenylmethoxyphenyl)methyl]purin-6-amine结构式

N,N-dimethyl-9-...

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4-(苄氧基)氯苄结构式

4-(苄氧基)氯苄

~%

N,N-dimethyl-9-[(4-phenylmethoxyphenyl)methyl]purin-6-amine结构式

N,N-dimethyl-9-...

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二甲胺结构式

6-chloro-9-(3,5-dichlorobenzyl)-9H-purine结构式

6-chloro-9-(3,5...

~89%

9-[(3,5-dichlorophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(3,5-dichlor...

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6-氯嘌呤结构式

~%

9-[(3,5-dichlorophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(3,5-dichlor...

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3,5-二氯苄基溴结构式

3,5-二氯苄基溴

~%

9-[(3,5-dichlorophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(3,5-dichlor...

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4-甲氧基溴苄结构式

4-甲氧基溴苄

6-氯嘌呤结构式

~28%

6-chloro-9-(4-methoxybenzyl)-9H-purine结构式

6-chloro-9-(4-m...

6-chloro-9-[(4-methoxyphenyl)methyl]purine结构式

6-chloro-9-[(4-...

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二甲胺结构式

6-chloro-9-(3-chlorophenylmethyl)-9H-purine结构式

6-chloro-9-(3-c...

~77%

9-[(3-chlorophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(3-chlorophe...

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间氯苄胺结构式

~%

9-[(3-chlorophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(3-chlorophe...

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二甲胺结构式

6-chloro-9-(3-methylbenzyl)-9H-purine结构式

6-chloro-9-(3-m...

~65%

N,N-dimethyl-9-[(3-methylphenyl)methyl]purin-6-amine结构式

N,N-dimethyl-9-...

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间甲基苄胺结构式

间甲基苄胺

~%

N,N-dimethyl-9-[(3-methylphenyl)methyl]purin-6-amine结构式

N,N-dimethyl-9-...

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6-chloro-N4-(3-methylbenzyl)pyrimidine-4,5-diamine结构式

6-chloro-N4-(3-...

~%

N,N-dimethyl-9-[(3-methylphenyl)methyl]purin-6-amine结构式

N,N-dimethyl-9-...

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6-二甲基氨基嘌呤结构式

6-二甲基氨基嘌呤

碘甲烷结构式

~26%

9H-Purin-6-amine,N,N,9-trimethyl结构式

9H-Purin-6-amin...

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6-氯嘌呤结构式

~%

9H-Purin-6-amine, N,N-dimethyl-9-(phenylmethyl)结构式

9H-Purin-6-amin...

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3-(6-chloro-purin-9-ylmethyl)-benzonitrile结构式

3-(6-chloro-pur...

二甲胺结构式

~85%

3-[[6-(dimethylamino)purin-9-yl]methyl]benzonitrile结构式

3-[[6-(dimethyl...

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二甲胺结构式

6-chloro-9-[(4-methoxyphenyl)methyl]purine结构式

6-chloro-9-[(4-...

~74%

9-[(4-methoxyphenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(4-methoxyph...

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6-氯嘌呤结构式

~%

9-[(4-methoxyphenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(4-methoxyph...

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二甲胺结构式

6-chloro-9-(3-iodobenzyl)-9H-purine结构式

6-chloro-9-(3-i...

~74%

9-[(3-iodophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(3-iodopheny...

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6-氯嘌呤结构式

~%

9-[(3-iodophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(3-iodopheny...

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3-碘苄溴结构式

~%

9-[(3-iodophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(3-iodopheny...

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溴化苄结构式

~%

9-benzyl-N-methylpurin-6-amine结构式

9-benzyl-N-meth...

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4-甲氧基溴苄结构式

4-甲氧基溴苄

~%

9-[(4-methoxyphenyl)methyl]-N,N-dimethylpurin-6-amine结构式

9-[(4-methoxyph...

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N,N-dimethyl-9-[(4-phenylmethoxyphenyl)methyl]purin-6-amine结构式

N,N-dimethyl-9-...

~59%

4-[[6-(dimethylamino)purin-9-yl]methyl]phenol结构式

4-[[6-(dimethyl...

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4-苄氧基苯甲醛结构式

4-苄氧基苯甲醛

~%

4-[[6-(dimethylamino)purin-9-yl]methyl]phenol结构式

4-[[6-(dimethyl...

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4-苄氧基苄醇结构式

4-苄氧基苄醇

~%

4-[[6-(dimethylamino)purin-9-yl]methyl]phenol结构式

4-[[6-(dimethyl...

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9-[4-(benzyloxy)benzyl]-6-chloro-9H-purine结构式

9-[4-(benzyloxy...

~%

4-[[6-(dimethylamino)purin-9-yl]methyl]phenol结构式

4-[[6-(dimethyl...

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4-(苄氧基)氯苄结构式

4-(苄氧基)氯苄

~%

4-[[6-(dimethylamino)purin-9-yl]methyl]phenol结构式

4-[[6-(dimethyl...

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3-羟基苯甲醇结构式

3-羟基苯甲醇

氯化苄结构式

~85%

3-苄氧基苯甲醇结构式

3-苄氧基苯甲醇

查看详情