Macrolide formation by free radical cyclization

NA Porter, VHT Chang

文献索引：Porter,N.A.; Chang,V.H.T. Journal of the American Chemical Society, 1987 , vol. 109, p. 4976

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被引用次数: 91

摘要

Conclusions The observed rate constants for the reactions of arylhalocarbenes with alkenes are accelerated by the application of moderate pressures. The magnitude of the activation volumes falls in the range-10 to-18 cm3/mol for rate constants that vary from ca. 5 X lo8 to ca. 1 X lo6 MI sl and are not sensitive to solvent. These results appear to rule out a late, two- bond transition state and a bipolar single-bond transition state, but they are consistent with ...