The synthesis of 2-and 3-aryl indoles and 1, 3, 4, 5-tetrahydropyrano [4, 3-b] indoles and their antibacterial and antifungal activity

…, WAL van Otterlo, SF van Vuuren, CB de Koning

文献索引：Leboho, Tlabo C.; Michael, Joseph P.; van Otterlo, Willem A.L.; van Vuuren, Sandy F.; de Koning, Charles B. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 4948 - 4951

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被引用次数: 48

摘要

A series of 2-and 3-aryl substituted indoles and two 1, 3, 4, 5-tetrahydropyrano [4, 3-b] indoles were synthesized from indole and 5-methoxyindole. The 2-aryl indoles were synthesized from the 1-(phenylsulfonyl) indole derivatives using magnesiation followed by iodination. The 2-iodinated compounds were then subjected to Suzuki–Miyaura reactions. In addition, the 3-aryl indoles were made from the corresponding 3-bromoindoles using ...