Synthesis of Flavones and γ??Benzopyranones Using Mild Sonogashira Coupling and 18??Crown??6 Ether Mediated 6??endo Cyclization

DW Chuang, M El??Shazly, D Balaji…

文献索引：Chuang, Da-Wei; El-Shazly, Mohamed; Balaji D., Barve; Chung, Yu-Ming; Chang, Fang-Rong; Wu, Yang-Chang European Journal of Organic Chemistry, 2012 , # 24 p. 4533 - 4540,8

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被引用次数: 7

摘要

Abstract An efficient method for the synthesis of flavones and γ-benzopyranones has been developed utilizing a mild Sonogashira coupling and 18-crown-6 ether mediated 6-endo cyclization of o-alkynoylphenyl acetates. By using this strategy, flavones and γ- benzopyranones bearing electron-donating groups, halogens, and simple alkyl substituents were synthesized in satisfactory yields.