Journal of medicinal chemistry

Trifluoromethyl Thiolsulfonates and Their Reactions with Mercaptans and Amines

JP Weidner, SS Block

文献索引：Weidner,J.P.; Block,S.S. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 1167 - 1170

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被引用次数: 8

摘要

2-Acetamidoethyl 2-(n-Decylamino) ethyI Disulfide Hydrochloride (2).-2-(n-Ilecylamino) ethyl 2-(n-decylamino) ethariethiolsulfonat, e dihydrochloride (1, 13.44 g, 25.0 mmoles)'was dissolved in a boiling mixture of CHdX arid EtOH (500 nil, 1: l),: tiid the soliiLion was cooled to room temperature. 2-Acetamidocthaiiethiol (2.98 g, 23.0 mmo1es) s then was added in one portion with stirring. The mixture was stirred for 3 hr more and then was chilled at, ea. ...