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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

9-Benzyl-6-(dimethylamino)-9H-purines with antirhinovirus activity

…, JA Linn, MP Krochmal, JWT Selway

文献索引：Kelley, James L.; Linn, James A.; Krochmal, Mark P.; Selway, J. W. T. Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2001 - 2004

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被引用次数: 28

摘要

A series of 9-benzyl-6-(dimethylamino)-9H-purines and 9-benzyl-2-chloro-6- (dimethylamino)-9H-purines were synthesized and tested in cell culture for activity against rhinovirus type 1B. The 9-benzylpurines that were unsubstituted in the 2-position had weak activity. However, introduction of a 2-chloro substituent resulted in a substantial increase in antiviral activity. One of the most active compounds, 2-chloro-6-(dimethylamino)-9-(4- ...

二甲胺结构式

2,6-dichloro-9-(4-ethylbenzyl)-9H-purine结构式

2,6-dichloro-9-...

~78%

2-chloro-9-[(4-ethylphenyl)methyl]-N,N-dimethylpurin-6-amine结构式

2-chloro-9-[(4-...

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二甲胺结构式

2,6-dichloro-9-(4-isopropylbenzyl)-9H-purine结构式

2,6-dichloro-9-...

~74%

2-chloro-N,N-dimethyl-9-[(4-propan-2-ylphenyl)methyl]purin-6-amine结构式

2-chloro-N,N-di...

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9-benzyl-2-chloro-N,N-dimethylpurin-6-amine结构式

9-benzyl-2-chlo...

~68%

9H-Purin-6-amine, N,N-dimethyl-9-(phenylmethyl)结构式

9H-Purin-6-amin...

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溴化苄结构式

~%

9H-Purin-6-amine, N,N-dimethyl-9-(phenylmethyl)结构式

9H-Purin-6-amin...

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9-苄基-2,6-二氯-9h-嘌呤结构式

9-苄基-2,6-二氯-9h-嘌呤

~%

9H-Purin-6-amine, N,N-dimethyl-9-(phenylmethyl)结构式

9H-Purin-6-amin...

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2,6-二氯嘌呤结构式

2,6-二氯嘌呤

~%

9H-Purin-6-amine, N,N-dimethyl-9-(phenylmethyl)结构式

9H-Purin-6-amin...

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二甲胺结构式

2,6-dichloro-9-(3-iodobenzyl)-9H-purine结构式

2,6-dichloro-9-...

~74%

2-chloro-9-[(3-iodophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

2-chloro-9-[(3-...

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二甲胺结构式

9-(3-chlorophenylmethyl)-2,6-dichloro-9H-purine结构式

9-(3-chlorophen...

~67%

2-chloro-9-[(3-chlorophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

2-chloro-9-[(3-...

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二甲胺结构式

2,6-dichloro-9-(3-methoxyphenylmethyl)-9H-purine结构式

2,6-dichloro-9-...

~88%

2-chloro-9-[(3-methoxyphenyl)methyl]-N,N-dimethylpurin-6-amine结构式

2-chloro-9-[(3-...

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4-氯溴苄结构式

2,6-二氯嘌呤结构式

2,6-二氯嘌呤

~35%

2,6-dichloro-9-[(4-chlorophenyl)methyl]purine结构式

2,6-dichloro-9-...

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2,6-二氯嘌呤结构式

2,6-二氯嘌呤

~%

9-[(4-aminophenyl)methyl]-2-chloro-N,N-dimethylpurin-6-amine结构式

9-[(4-aminophen...

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2,6-dichloro-9-(4-nitro-benzyl)-9H-purine结构式

2,6-dichloro-9-...

~%

9-[(4-aminophenyl)methyl]-2-chloro-N,N-dimethylpurin-6-amine结构式

9-[(4-aminophen...

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4-硝基溴化苄结构式

4-硝基溴化苄

~%

9-[(4-aminophenyl)methyl]-2-chloro-N,N-dimethylpurin-6-amine结构式

9-[(4-aminophen...

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二甲胺结构式

2,6-dichloro-9-[(4-chlorophenyl)methyl]purine结构式

2,6-dichloro-9-...

~85%

2-chloro-9-[(4-chlorophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

2-chloro-9-[(4-...

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4-氯溴苄结构式

~%

2-chloro-9-[(4-chlorophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

2-chloro-9-[(4-...

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2,6-二氯嘌呤结构式

2,6-二氯嘌呤

~%

2-chloro-9-[(4-chlorophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

2-chloro-9-[(4-...

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二甲胺结构式

2,6-dichloro-9-(3,4-dichlorophenylmethyl)-9H-purine结构式

2,6-dichloro-9-...

~9%

2-chloro-9-[(3,4-dichlorophenyl)methyl]-N,N-dimethylpurin-6-amine结构式

2-chloro-9-[(3,...

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9-苄基-2,6-二氯-9h-嘌呤结构式

9-苄基-2,6-二氯-9h-嘌呤

二甲胺结构式

~72%

9-benzyl-2-chloro-N,N-dimethylpurin-6-amine结构式

9-benzyl-2-chlo...

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溴化苄结构式

~%

9-benzyl-2-chloro-N,N-dimethylpurin-6-amine结构式

9-benzyl-2-chlo...

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2,6-二氯嘌呤结构式

2,6-二氯嘌呤

~%

9-benzyl-2-chloro-N,N-dimethylpurin-6-amine结构式

9-benzyl-2-chlo...

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2-chloro-N,N-dimethyl-9-[(3-nitrophenyl)methyl]purin-6-amine结构式

2-chloro-N,N-di...

~56%

9-[(3-aminophenyl)methyl]-2-chloro-N,N-dimethylpurin-6-amine结构式

9-[(3-aminophen...

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