Tetrahedron Letters

Ru (II)-Pheox catalyzed N–H insertion reaction of diazoacetamides: synthesis of N-substituted α-aminoamides

S Chanthamath, S Thongjareun, K Shibatomi…

文献索引：Chanthamath, Soda; Thongjareun, Songkharm; Shibatomi, Kazutaka; Iwasa, Seiji Tetrahedron Letters, 2012 , vol. 53, # 36 p. 4862 - 4865

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被引用次数: 5

摘要

An efficient protocol for the preparation of α-aminoamides was developed via the Ru (II)-dm- Pheox catalyzed N–H insertion reaction of various diazoacetamides with several amines, including aniline. This catalytic N–H insertion reaction was also applied to the synthesis of 2- (2-methylquinolin-4-ylamino)-N-phenylacetamide, a potential antileishmanial agent.