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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo-and dipyridodiazepinones

KD Hargrave, JR Proudfoot, KG Grozinger…

文献索引：Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241

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被引用次数: 215

摘要

Novel pyrido [2, 3-b][1, 4] benzodiazepinones (I), pyrido [2, 3-b][1, 5] benzodiazepinones (II), and dipyrido [3, 2-b: 2', 3'-e][1, 4] diazepinones (111) were found to inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase in vitro at concentrations as low as 35 nM. In all three series, small substituents (eg, methyl, ethyl, acetyl) are preferred at the lactam nitrogen, whereas slightly larger alkyl moieties (eg, ethyl, cyclopropyl) are favored ...

2-氯烟酸结构式

二氨基甲苯结构式

二氨基甲苯

~50%

7-methyl-6,11-dihydropyrido[3,2-c][1,5]benzodiazepin-5-one结构式

7-methyl-6,11-d...

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2-氯烟酸结构式

~%

6-methyl-11H-pyrido[3,2-c][1,5]benzodiazepin-5-one结构式

6-methyl-11H-py...

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邻苯二胺(OPD)结构式

邻苯二胺(OPD)

~%

6-methyl-11H-pyrido[3,2-c][1,5]benzodiazepin-5-one结构式

6-methyl-11H-py...

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6,11-二氢吡啶并[3,2-c][1,5]苯二氮卓-5-酮结构式

6,11-二氢吡啶并[3,2-...

碘甲烷结构式

~%

6-methyl-11H-pyrido[3,2-c][1,5]benzodiazepin-5-one结构式

6-methyl-11H-py...

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2-氯烟酸结构式

碘乙烷结构式

4-氯邻苯二胺结构式

4-氯邻苯二胺

碘甲烷结构式

~%

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2-氯烟酸结构式

~%

6-ethyl-11H-pyrido[3,2-c][1,5]benzodiazepin-5-one结构式

6-ethyl-11H-pyr...

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邻苯二胺(OPD)结构式

邻苯二胺(OPD)

~%

6-ethyl-11H-pyrido[3,2-c][1,5]benzodiazepin-5-one结构式

6-ethyl-11H-pyr...

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碘乙烷结构式

6,11-二氢吡啶并[3,2-c][1,5]苯二氮卓-5-酮结构式

6,11-二氢吡啶并[3,2-...

~%

6-ethyl-11H-pyrido[3,2-c][1,5]benzodiazepin-5-one结构式

6-ethyl-11H-pyr...

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3-氨基-2,6-二氯吡啶结构式

3-氨基-2,6-二氯吡啶

~%

N-(2,6-dichloropyridin-3-yl)-2-(ethylamino)pyridine-3-carboxamide结构式

N-(2,6-dichloro...

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2-氯-3-吡啶羧酸结构式

2-氯-3-吡啶羧酸

~%

N-(2,6-dichloropyridin-3-yl)-2-(ethylamino)pyridine-3-carboxamide结构式

N-(2,6-dichloro...

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2-氯烟酸结构式

~%

11-ethyl-8-hydroxy-6-methylpyrido[3,2-c][1,5]benzodiazepin-5-one结构式

11-ethyl-8-hydr...

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4-甲氧基邻苯二胺结构式

4-甲氧基邻苯二胺

~%

11-ethyl-8-hydroxy-6-methylpyrido[3,2-c][1,5]benzodiazepin-5-one结构式

11-ethyl-8-hydr...

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6,11-二氢吡啶并[3,2-c][1,5]苯二氮卓-5-酮结构式

6,11-二氢吡啶并[3,2-...

~%

6-prop-2-enyl-11H-pyrido[3,2-c][1,5]benzodiazepin-5-one结构式

6-prop-2-enyl-1...

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2-氯烟酸结构式

~%

6-prop-2-enyl-11H-pyrido[3,2-c][1,5]benzodiazepin-5-one结构式

6-prop-2-enyl-1...

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邻苯二胺(OPD)结构式

邻苯二胺(OPD)

~%

6-prop-2-enyl-11H-pyrido[3,2-c][1,5]benzodiazepin-5-one结构式

6-prop-2-enyl-1...

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6-甲基-3-氨基-2-氯吡啶结构式

6-甲基-3-氨基-2-氯吡啶

~%

11-ethyl-2,5-dimethyldipyrido[2,3-b:2',3'-f][1,4]diazepin-6-one结构式

11-ethyl-2,5-di...

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2-氯-3-吡啶羧酸结构式

2-氯-3-吡啶羧酸

~%

11-ethyl-2,5-dimethyldipyrido[2,3-b:2',3'-f][1,4]diazepin-6-one结构式

11-ethyl-2,5-di...

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2-chloro-N-(2-chloro-6-methylpyridin-3-yl)nicotinamide结构式

2-chloro-N-(2-c...

~%

11-ethyl-2,5-dimethyldipyrido[2,3-b:2',3'-f][1,4]diazepin-6-one结构式

11-ethyl-2,5-di...

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11-ethyl-2-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one结构式

11-ethyl-2-meth...

~%

11-ethyl-2,5-dimethyldipyrido[2,3-b:2',3'-f][1,4]diazepin-6-one结构式

11-ethyl-2,5-di...

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2-氯-3-氨基吡啶结构式

2-氯-3-氨基吡啶

~%

11-ethyl-5H-dipyrido[2,3-b:2',3'-f][1,4]diazepin-6-one结构式

11-ethyl-5H-dip...

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2-氯-3-吡啶羧酸结构式

2-氯-3-吡啶羧酸

~%

11-ethyl-5H-dipyrido[2,3-b:2',3'-f][1,4]diazepin-6-one结构式

11-ethyl-5H-dip...

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