A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

Y Yasohara, K Miyamoto, N Kizaki, J Hasegawa…

文献索引：Yasohara, Yoshihiko; Miyamoto, Kenji; Kizaki, Noriyuku; Hasegawa, Junzo; Ohashi, Takehisa Tetrahedron Letters, 2001 , vol. 42, # 19 p. 3331 - 3333

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被引用次数: 16

摘要

The search for systemic fungal infections continues to be important because of the growing population of immunocompromised patients. 1 There is, therefore, a need for more effective antifungal agents. Two new antifungal agents, ZD0870 2 and Sch45450, 3 show potent broad-spectrum antifungal activities compared to other clinically used antifungal agents. Because these compounds contain chiral centers comprised of a difluorobenzene and a triazole group, an optically ...