Bioorganic & medicinal chemistry letters

An alternative synthetic route for an antidiabetic drug, rosiglitazone

DV Jawale, UR Pratap, RA Mane

文献索引：Jawale, Dhanaji V.; Pratap, Umesh R.; Mane, Ramrao A. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 924 - 928

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被引用次数: 13

摘要

A convenient and scalable four-step novel route has been developed for the synthesis of rosiglitazone (8), an antidiabetic drug. This multistep route requires 4-fluoro benzaldehyde (4), 2, 4-thiazolidinedione (6) and 2-chloro pyridine (1) as key reactants and gives overall better yield of rosiglitazone. In addition, some steps have been accelerated, which leads to an overall time saving of 10h.