Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core

…, Q Cao, MH Constantino, MA Schwartz…

文献索引：Jin, Yonghao; Roycik, Mark D.; Bosco, Dale B.; Cao, Qiang; Constantino, Manuel H.; Schwartz, Martin A.; Sang, Qing-Xiang Amy Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4357 - 4373

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被引用次数: 5

摘要

New series of pyrrolidine mercaptosulfide, 2-mercaptocyclopentane arylsulfonamide, and 3- mercapto-4-arylsulfonamidopyrrolidine matrix metalloproteinase inhibitors (MMPIs) were designed, synthesized, and evaluated. Exhibiting unique properties over other MMPIs (eg, hydroxamates), these newly reported compounds are capable of modulating activities of several MMPs in the low nanomolar range, including MMP-2 (∼ 2 to 50 nM), MMP-13 (∼ ...