9H-Xanthene-9-carboxylic acid [1, 2, 4] oxadiazol-3-yl-and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers

…, S Jolidon, F Knoflach, V Mutel, J Wichmann

文献索引：Vieira, Eric; Huwyler, Joerg; Jolidon, Synese; Knoflach, Frederic; Mutel, Vincent; Wichmann, Juergen Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4628 - 4631

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被引用次数: 49

摘要

Small molecule mGluR1 enhancers based on the lead compound (9H-xanthene-9-carbonyl)- carbamic acid butyl ester derived from random-screening hit diphenylacetyl-carbamic acid ethyl ester were designed and synthesized as useful pharmacological tools for the study of the physiological roles mediated by mGlu1 receptors. The synthesis and the structure– activity relationship of this new class of positive allosteric modulators of mGlu1 receptors ...