. beta.-Amino ketones. Synthesis and some biological activities in mice of 3, 3-dialkyl-1, 2, 3, 4-tetrahydro-4-quinolinones and related Mannich bases

AB Daruwala, JE Gearien, WJ Dunn III…

文献索引：Daruwala,A.B. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, # 8 p. 819 - 824

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被引用次数: 15

摘要

ported to have analgetic properties1 (Haffner tail-pinch method2), Sufficient biological activity was exhibited by several members in the series to warrant further investigation of a number of related compounds (Table I). Mannich Bases. From prior studies which investigated@-dimethylaminopropiophenones, ArCOCH2CH2NMe2, for analgetic activity, there emerged the lead compound 5 (Table I). In this particular structure, the active ...