Act Pol Pharm

Synthesis, antimicrobial evaluation, QSAR and in silico admet studies of decanoic acid derivatives

A Kumar, S Singh, S Jain, P Kumar

文献索引：Kumar, Ashwani; Singh, Surender; Jain, Sandeep; Kumar, Parvin Acta Poloniae Pharmaceutica - Drug Research, 2011 , vol. 68, # 2 p. 191 - 204

全文：HTML全文

被引用次数: 6

摘要

Abstract: Various derivatives of decanoic acid (CD) have been synthesized and evaluated against Gram positive B. subtilis, S. aureus and Gram negative E. coli bacteria as well as against fungi C. albicans and A. niger. Quantitative structure activity relationship (QSAR) models for antimicrobial activities were developed using multiple linear regression and cross validated by leave one out (LOO) approach. QSAR studies indicated that activity ...