Chemical Communications

A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18 F] trifluoromethyl groups

PJ Riss, FI Aigbirhio

文献索引：Riss, Patrick J.; Aigbirhio, Franklin I. Chemical Communications, 2011 , vol. 47, # 43 p. 11873 - 11875

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被引用次数: 30

摘要

A procedure for the radiosynthesis of aliphatic [18F] trifluoromethyl groups by reacting 1, 1- difluorovinyl precursors with [18F] fluoride ions, resulting in the equivalent of direct nucleophilic addition of H [18F] F, has been developed. A variety of 18F-labelled model compounds were then obtained and two potential [18F] radiotracers were synthesised by a two step process starting from 1, 1-difluorovin-2-yl 4-toluenesulfonate. The method is ...