The oxidative dealkylation of tertiary amides: mechanistic aspects

J Iley, R Tolando

文献索引：Iley, Jim; Tolando, Roberto Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 11 p. 2328 - 2336

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被引用次数: 15

摘要

N-(But-3-enyl)-N-methylbenzamide 14a undergoes microsomal oxidation by rat liver microsomes to yield both N-methyl-and N-(but-3-enyl) benzamides 18a and 19, the products of N-dealkylation. Cyclic products, that could be derived from a carbon-centred radical formed by hydrogen atom abstraction from the N-methyl group, were not observed. When generated independently, this carbon-centred radical underwent cyclisation, the 5-exo-trig ...