Tetrahedron letters

Determination of the absolute configurations and total synthesis of new immunosuppressants, mycestericins E and G

T Fuiita, N Hamamichi, T Matsuzaki, Y Kitao, M Kiuchi…

文献索引：Fujita, Tetsuro; Hamamichi, Norimitsu; Matsuzaki, Tohru; Kitao, Yuki; Kiuchi, Masatoshi; Node, Manabu; Hirose, Ryoji Tetrahedron Letters, 1995 , vol. 36, # 47 p. 8599 - 8602

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被引用次数: 30

摘要

The absolute configurations of two new immunosuppressants, mycestericins E (1) and G (2), were establishied and both compounds were synthesized starting from 1, 8-octanediol and a fully protected methyl (2S, 4R)-oxazolidine-4-carboxylate 3. Compounds 5 and 22, with a (l'R)-hydroxyl group, were prepared from the β-keto esters 4 and 21, respectively, by stereoselective reduction with metal borohydrides.