Side??Chain Retention During Lithiation of 4??Picoline and 3, 4??Lutidine: Easy Access to Molecular Diversity in Pyridine Series

T Kaminski, P Gros, Y Fort

文献索引：Kaminski, Thomas; Gros, Philippe; Fort, Yves European Journal of Organic Chemistry, 2003 , # 19 p. 3855 - 3860

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被引用次数: 23

摘要

Abstract The first direct ring-selective lithiation of 4-picoline and 3, 4-lutidine has been achieved through the use of BuLi/LiDMAE aggregates to prevent the usual side-chain metallation. Several functionalities have been introduced at the C-2, C-6 and C-5 positions by ring-selective sequential lithiation, opening a simple and fast route to polysubstituted pyridine building blocks.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, ...