Tetrahedron

New 5-(2-ethenylsubstituted)-3 (2H)-furanones with in vitro antiproliferative activity

S Chimichi, M Boccalini, B Cosimelli, F Dall'Acqua…

文献索引：Chimichi, Stefano; Boccalini, Marco; Cosimelli, Barbara; Dall'Acqua, Francesco; Viola, Giampietro Tetrahedron, 2003 , vol. 59, # 28 p. 5215 - 5223

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被引用次数: 36

摘要

A convenient route to new 3 (2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived ...

~72%

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~76%

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~79%

14400-67-0

2,5-二甲基-3(2H)-呋喃酮

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Ethyl 5-substituted-3-isoxazolecarboxylates as starting mate...

[Baraldi, Pier Giovanni; Barco, Achille; Benetti, Simonetta; Manfredini, Stefano; Pollini, Gian Piero; Simoni, Daniele Tetrahedron Letters, 1984 , vol. 25, # 38 p. 4313 - 4316]

Reduction of Δ 2-isoxazolines-2. A facile synthesis of 3 (2H...

[Curran, Dennis P.; Singleton, David H. Tetrahedron Letters, 1983 , vol. 24, # 20 p. 2079 - 2082]