The Journal of Organic Chemistry

A convenient synthetic route to methylated silacyclohexanes

BT Nguyen, FK Cartledge

文献索引：Nguyen, Binh T.; Cartledge, Frank K. Journal of Organic Chemistry, 1986 , vol. 51, # 12 p. 2206 - 2210

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被引用次数: 20

摘要

The von Braun degradation of substituted piperidines is a general and economical route to a variety of substituted primary and secondary a, w-dibromopentanes. Grignard ring closure procedures have been carried out with seven different dibromopentanes in moderate to good yields. Ring closures with MeCISiClz lead to product mixtures which are appreciably enriched in one isomer, affording a convenient entry into a variety of derivatives which can ...