Convenient Syntheses of Daunomycinone??7??D??Glucuronides and Doxorubicinone??7??D??Glucuronides
YS Rho, SY Kim, WJ Kim, YK Yun, HS Sin…
文献索引：Rho, Young S.; Kim, Sun Y.; Kim, Wan-Joong; Yeo, Keun Yun; Hong, Sig Sin; Dong, Jin Yoo Synthetic Communications, 2004 , vol. 34, # 19 p. 3497 - 3511
Abstract The first synthesis of new doxorubicin and daunomycin analogs containing glucuronic acid moieties instead of daunosamine are described. The desired products, daunomycinone??7??D??glucuronide (DM7G, 10) and doxorubicinone??7??D??glucuronide (DX7G, 11) were conveniently prepared through the glycosylation at 7??hydroxyl group of daunomycinone (4) or 14??acetoxydoxorubicinone (6) with glucuronic acid derivative 7 by ...
