Template-constrained cyclic peptides: design of high-affinity ligands for GPIIb/IIIa

…, W DeGrado, A Dwivedi, A Parthasarathy…

文献索引：Jackson, Sharon; DeGrado, William; Dwivedi, Anil; Parthasarathy, Anju; Higley, Anne; Krywko, James; Rockwell, Arlene; Markwalder, Jay; Wells, Greg; Wexler, Ruth; Mousa, Shaker; Harlow, Richard Journal of the American Chemical Society, 1994 , vol. 116, # 8 p. 3220 - 3230

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被引用次数: 163

摘要

Abstract: Although peptides adopt a large ensemble of conformations in aqueous solution, they are generally believed to bind to a receptor in a unique conformation. Thus, there is considerable interest in devising methods to restrict the conformational freedom of peptides. One such approach involves tying the amino and carboxy terminal endsof the peptide onto a semirigid template that will lock the intervening peptide backbone into a single conformer ...