Selected sulfonyl compounds as anticancer/antimalarial agents

…, RL Paddock, DB Thompson, I Crandall, M Ciach…

文献索引：Langler, Richard F.; Paddock, Robert L.; Thompson, David B.; Crandall, Ian; Ciach, Michelle; Kain, Kevin C. Australian Journal of Chemistry, 2003 , vol. 56, # 11 p. 1127 - 1133

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被引用次数: 14

摘要

Abstract The synthesis and biological testing of a series of sulfonyl phenols and sulfonyl aryl methyl ethers has revealed that p-methoxyphenyl p-toluenesulfonate is a very selective and effective antimalarial agent which shows pronounced activity against human skin cancer cells. Application of a counter-attack strategy permits the direct preparation of the requisite tosylate ether from the bis (tosylate) of dihydroquinone.