Discovery of a Novel and Potent Human and Rat. BETA. 3-Adrenergic Receptor Agonist,[3-[(2R)-[[(2R)-(3-Chlorophenyl)-2-hydroxyethyl] amino] propyl]-1H-indol-7- …

H Harada, Y Hirokawa, K Suzuki, Y Hiyama…

文献索引：Harada, Hiroshi; Hirokawa, Yoshimi; Suzuki, Kenji; Hiyama, Yoichi; Oue, Mayumi; Kawashima, Hitoshi; Kato, Hiroshi; Yoshida, Naoyuki; Furutani, Yasuji; Kato, Shiro Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 2 p. 184 - 198

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被引用次数: 39

摘要

In search for potent and selective β 3-adrenergic receptor (β 3-AR) agonists as potential drugs for the treatment of type II diabetes and obesity, a novel series of 1-(3-chlorophenyl)-2- aminoethanol derivatives were prepared and evaluated for their biological activity at human β 1-, β 2-, and β 3-ARs and rat β 3-AR expressed in Chinese hamster ovary (CHO) cells. Replacement of the right-hand side (RHS, benzene ring) in the 'first generation'β 3-AR ...