A NOVEL SYNTHESIS OF 3-SUBSTITUTED MDAZOLIDIN-2-ONE-1-CARBONYL CHLORIDES

W Su, K Huang, Y Zhang

文献索引：Su, Weike; Huang, Kewei; Zhang, Yongmin Organic Preparations and Procedures International, 2000 , vol. 32, # 5 p. 498 - 501

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摘要

3-Substituted imidazolidin-Zone-1-carbony1 chlorides (SICs) are very important intermediates for the semi-synthesis of p-lactam antibiotics.'-6 SICs have been conveniently prepared by the reaction of N-substituted imidazolidin-2-ones with phosgene.'-'However, phosgene has become commerically inaccessible as a common and useful reagent because it is a highly toxic, dangerous gas. Such a situation prompted us to investigate a ...