European journal of medicinal chemistry

Synthesis of a new series of 2, 7-diazaspiro [3.5] nonan-1-ones and study of their cholinergic properties

G Cignarella, S Villa, D Barlocco

文献索引：Cignarella, G.; Villa, S.; Barlocco, D. European Journal of Medicinal Chemistry, 1994 , vol. 29, # 1 p. 115 - 120

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被引用次数: 0

摘要

Abstract A new series of substituted 2, 7-diazaspiro [3.5] nonan-1-ones (1a-I), structurally related to the muscarinic agonist RS-86, has been synthesized and tested for cholinergic properties both in vitro and in vivo. None of the compounds showed significant cholinergic properties at either the central or peripheral level. A possible explanation for the lack of activity is given.