Substituted 3-(arylmethylene) isoindolin-1-ones can be efficiently synthesized from various ynamides and boronic acids by palladium-catalyzed Heck–Suzuki–Miyaura domino reactions. This methodology has been applied to the total synthesis of lennoxamine and a concise route to this isoindolobenzazepine alkaloid was achieved in eight steps from 2, 3- dimethoxybenzoic acid via a key intermediate ynamide.
