A novel class of biologically active compound 2, 7-dihydro-3H-pyridazino [3 ', 4 ': 4, 5] indolo [3, 2-c] quinoline-3, 13 (12H)-dione (10a-b) has been achieved efficiently and quickly under solvent free conditions in an open vessel microwave system. The multi step one pot synthesis involved the reaction of 8, 9, 10, 11-tetrahydro-6H-indolo [3, 2-c] quinoline-6, 7 (5H)-dione (6a-d) and glyoxylic acid monohydrate followed by cyclocondensation with ...