Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents

KJ Kayser-Bricker, MP Glenn, SH Lee, SM Sebti…

文献索引：Kayser-Bricker, Katherine J.; Glenn, Matthew P.; Lee, Sang Hoon; Sebti, Said M.; Cheng, Jin Q.; Hamilton, Andrew D. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 4 p. 1764 - 1771

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被引用次数: 19

摘要

Akt has emerged as a critical target for the development of anti-cancer therapies. It has been found to be amplified, overexpressed, or constitutively activated in numerous human malignancies with oncogenesis derived from the simultaneous promotion of cell survival and suppression of apoptosis. A valuable alternative to the more common ATP-mimetic based chemotherapies is a substrate-mimetic approach, which has the potential advantage of ...