Tetrahedron

The synthesis of baclofen and GABOB via Rh (II) catalyzed intramolecular C–H insertion of α-diazoacetamides

Z Chen, Z Chen, Y Jiang, W Hu

文献索引：Chen, Zhenliang; Chen, Zhiyong; Jiang, Yaozhong; Hu, Wenhao Tetrahedron, 2005 , vol. 61, # 6 p. 1579 - 1586

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被引用次数: 28

摘要

In the transition metal catalyzed C–H insertion of α-diazoacetamide, regioselectivity has remained a major challenge. It has been well documented that regioselectivity depends highly on the substitutents of diazo carbon, the N-substitutents on the amide moiety, and the electrophilicity of the catalysts. 5 In the past twenty years, some examples have been reported on the application of the intramolecular C–H insertion of α-diazoacetamide. 6 High regioselectivity has been ...