Identification and specificity studies of small-molecule ligands for SH3 protein domains

…, C Stojkoski, KM Branson, JF Cawthray…

文献索引：Inglis, Steven R.; Stojkoski, Cvetan; Branson, Kim M.; Cawthray, Jacquie F.; Fritz, Daniel; Wiadrowski, Emma; Pyke, Simon M.; Booker, Grant W. Journal of Medicinal Chemistry, 2004 , vol. 47, # 22 p. 5405 - 5417

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被引用次数: 62

摘要

The Src Homology 3 (SH3) domains are small protein-protein interaction domains that bind proline-rich sequences and mediate a wide range of cell-signaling and other important biological processes. Since deregulated signaling pathways form the basis of many human diseases, the SH3 domains have been attractive targets for novel therapeutics. High-affinity ligands for SH3 domains have been designed; however, these have all been peptide- ...