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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

… in α-Trimethylsilyloxy-β-oxo Phosphonates and α-Ethoxy-β-oxo Phosphonates. The Synthesis of Unsymmetrical α-Hydroxy Ketones Utilizing 1: 1 Carbonyl Adducts of …

M Sekine, M Nakajima, T Hata

文献索引：Sekine, Mitsuo; Nakajima, Masashi; Hata, Tsujiaki Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 1 p. 218 - 223

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被引用次数: 7

摘要

α-Lithiated diethyl α-(trimethylsilyloxy) benzylphosphonate underwent facile acylation with various acylating agents to afford the corresponding α-acylated products in good yields. On treatment of the α-acylated products with 1 M NaOH–EtOH (1: 1, v/v) the P–C bond was cleaved with elimination of diethyl phosphate to give α-hydroxy ketones predominantly. On the other hand, when diethyl α-acyl-α-ethoxybenzylphosphonates were treated under the ...

diethyl α-benzoyl-α-[(trimethylsilyl)oxy]benzylphosphonate结构式

diethyl α-benzo...

~64%

2-diethoxyphosphoryl-2-hydroxy-1,2-diphenylethanone结构式

2-diethoxyphosp...

[diethoxyphosphoryl(phenyl)methoxy]-trimethylsilane结构式

[diethoxyphosph...

~%

2-diethoxyphosphoryl-2-hydroxy-1,2-diphenylethanone结构式

2-diethoxyphosp...

苯甲酰氯结构式

~%

2-diethoxyphosphoryl-2-hydroxy-1,2-diphenylethanone结构式

2-diethoxyphosp...

[diethoxyphosphoryl(phenyl)methoxy]-trimethylsilane结构式

[diethoxyphosph...

~%

2-hydroxy-1-phenylpentan-1-one结构式

2-hydroxy-1-phe...

ethyl-(α-chloro-benzyl)-ether结构式

ethyl-(α-chloro...

亚磷酸二乙酯结构式

亚磷酸二乙酯

~%

[diethoxyphosphoryl(ethoxy)methyl]benzene结构式

[diethoxyphosph...

diethyl α-ethoxy-α-benzoylbenzylphosphonate结构式

diethyl α-ethox...

~%

[diethoxyphosphoryl(ethoxy)methyl]benzene结构式

[diethoxyphosph...

苯甲酸结构式

[diethoxyphosphoryl(phenyl)methoxy]-trimethylsilane结构式

[diethoxyphosph...

~%

2-hydroxy-3-methyl-1-phenylbutan-1-one结构式

2-hydroxy-3-met...

diethyl 1-trimethylsilyloxy-3-methyl-2-oxo-1-phenylbutylphosphonate结构式

diethyl 1-trime...

~%

2-hydroxy-3-methyl-1-phenylbutan-1-one结构式

2-hydroxy-3-met...

1-hydroxy-3-methyl-1-phenylbutan-2-one结构式

1-hydroxy-3-met...

diethyl α-trimethylsilyloxy-α-(4-methoxybenzoyl)benzylphosphonate结构式

diethyl α-trime...

~88%

1-(4-甲氧基苯基)-2-苯基-1,2-二酮结构式

1-(4-甲氧基苯基)-2-苯...

2-hydroxy-1-(4-methoxyphenyl)-2-phenyl-ethanone结构式

2-hydroxy-1-(4-...

[diethoxyphosphoryl(phenyl)methoxy]-trimethylsilane结构式

[diethoxyphosph...

~%

2-hydroxy-1-(4-methoxyphenyl)-2-phenyl-ethanone结构式

2-hydroxy-1-(4-...

对甲氧基苯甲酰氯结构式

对甲氧基苯甲酰氯

~%

2-hydroxy-1-(4-methoxyphenyl)-2-phenyl-ethanone结构式

2-hydroxy-1-(4-...

diethyl α-ethoxy-α-benzoylbenzylphosphonate结构式

diethyl α-ethox...

~%

[diethoxyphosphoryl(ethoxy)methyl]benzene结构式

[diethoxyphosph...

苯甲酸结构式

diethyl α-trimethylsilyloxy-α-(4-chlorobenzoyl)benzylphosphonate结构式

diethyl α-trime...

~72%

对氯联苯酰结构式

对氯联苯酰

2-(4-chlorophenyl)-2-hydroxy-1-phenylethanone结构式

2-(4-chlorophen...

[diethoxyphosphoryl(phenyl)methoxy]-trimethylsilane结构式

[diethoxyphosph...

~%

2-(4-chlorophenyl)-2-hydroxy-1-phenylethanone结构式

2-(4-chlorophen...

4-氯苯甲酰氯结构式

4-氯苯甲酰氯

~%

2-(4-chlorophenyl)-2-hydroxy-1-phenylethanone结构式

2-(4-chlorophen...

diethyl α-trimethylsilyloxy-α-(4-methoxybenzoyl)benzylphosphonate结构式

diethyl α-trime...

~3%

1-(4-甲氧基苯基)-2-苯基-1,2-二酮结构式

1-(4-甲氧基苯基)-2-苯...

2-hydroxy-1-(4-methoxyphenyl)-2-phenyl-ethanone结构式

2-hydroxy-1-(4-...

[diethoxyphosphoryl(phenyl)methoxy]-trimethylsilane结构式

[diethoxyphosph...

~%

1-(4-甲氧基苯基)-2-苯基-1,2-二酮结构式

1-(4-甲氧基苯基)-2-苯...

对甲氧基苯甲酰氯结构式

对甲氧基苯甲酰氯

~%

1-(4-甲氧基苯基)-2-苯基-1,2-二酮结构式

1-(4-甲氧基苯基)-2-苯...