Potential organ or tumor imaging agents. 11. Radioiodinated tyramines

RE Counsell, TD Smith, VV Ranade…

文献索引：Counsell,R.E. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 684 - 687

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被引用次数: 18

摘要

The lack of suitable radiolabeled agents for photoscanning adrenal medullary tumors prompted synthesis of 4-hydroxy-3-iodo-(2), 3-hydroxy-6-iodo-(3), and 3-hydroxy- 54odophenylethylamine (4) radiolabeled with iodine-125. Radioiodination by isotope exchange was unsuccessful for 3 and 4, but the former was obtained by the direct radioiodination of rn-tyramine hydrochloride. Tissue distribution studies in dogs with 2 and ...